| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide immunoconjugate formulations that are substantially free of particles and/or aggregates. <P>SOLUTION: The immunoconjugate formulation that is substantially free of particles includes: an immunoconjugate and excipients selected from sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The invention also provides an immunoconjugate formulation that is substantially free of aggregates and includes: an immunoconjugate and excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates. <P>COPYRIGHT: (C)2013,JPO&INPIT |
