NOVEL INTERMEDIATES FOR THE PREPARATION OF HIGHLY PURE APREPITANT OR FOSAPREPITANT

摘要

The invention provides a salt, preferably in crystalline form, of (2R,3S)-2-[(R)-1-(3,5-Bis- trifluoromethylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine (BFM2) with a ?,?'-substituted tartaric acid derivative. Furthermore, a composition comprising said salt is provided. In another embodiment, a process for the preparation of said salt or said composition is provided. In a further embodiment, a process for the preparation of aprepitant or fosaprepitant is provided. One embodiment refers to the use of a salt or a composition according to the invention for the preparation of aprepitant or fosaprepitant. A further embodiment refers to aprepitant or fosaprepitant obtained or obtainable according to the process according to the invention. A further embodiment refers to a composition comprising aprepitant or fosaprepitant obtained or obtainable according to the process of the invention, preferably for use as a medicament (Formula (A)).