发明名称 |
METHODS OF CONTROLLING VENOUS IRRITATION ASSOCIATED WITH THE TREATMENT OF A CARDIAC DISORDER |
摘要 |
A pharmaceutical composition comprising (S)-methyl-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate in a concentration between about 75 mM and about 150 mM, which is substantially free of the R-isomer or pharmaceutically acceptable salt thereof, is provided. A method of treating a cardiac disorder is also provided and includes administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising (S)-methyl-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride, wherein the (S)-methyl-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride is present at a concentration between about 75 mM and about 150 mM and wherein the pharmaceutical composition is substantially free of (R)-methyl-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate or pharmaceutically acceptable salt thereof.
|
申请公布号 |
US2012277309(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
US201213358949 |
申请日期 |
2012.01.26 |
申请人 |
GASS JEROME H.;MCKEE JEFF;RABINOW BARRETT;BAXTER HEALTHCARE S.A.;BAXTER INTERNATIONAL INC. |
发明人 |
GASS JEROME H.;MCKEE JEFF;RABINOW BARRETT |
分类号 |
A61K31/216;A61P9/00;A61P9/06;A61P9/12;C07C229/34 |
主分类号 |
A61K31/216 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|