摘要 |
A direct trifluoromethylation method preferably using a trifluoromethane as a fluoromethylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifluoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur. |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA;PRAKASH, G.K. SURYA;JOG, PARAG, V.;BATAMACK, PATRICE, T.D.;OLAH, GEORGE, A. |
发明人 |
PRAKASH, G.K. SURYA;JOG, PARAG, V.;BATAMACK, PATRICE, T.D.;OLAH, GEORGE, A. |