| 摘要 |
The present invention provides for methods of removing genomic DNA from a biological sample comprising a target molecule. In some embodiments, the method comprises contacting the sample to a cation exchange ligand under conditions such that: (a) positively charged complexes comprising genomic DNA from the sample bind the cation exchange ligand; and (b) the target molecule does not substantially bind to the cation exchange ligand; and separating the sample from the positively-charged complexes bound to the cation exchange ligand to produce a sample having a reduced amount of genomic DNA. In some embodiments, the method further comprises, after the separating, performing at least 10 one more target molecule purification step on the sample having a reduced amount of genomic DNA.
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