发明名称 |
NOVEL PEPTIDE INHIBITORS OF SEROTONIN 5-HT2C RECEPTOR:PTEN INTERACTION |
摘要 |
The 5-HT 2C receptor is implicated in feeding, obesity, palatable food reward, metabolic disorders, drug addiction, anxiety, stress sensitivity, and depression. Embodiments of the invention are directed to modulation of the 5 -HT 2cR. Certain aspects are directed to therapies for the above referenced conditions. In certain aspects, therapeutic agents are identified that disrupt the 5-HT2cR:PTEN complex activating 5-HT2CR signaling. In certain aspects the complex is disrupted by a disrupter. The disrupter can be a peptide that displaces PTEN from the 5-HT 2cR:PTEN complex or inhibits the formation of the complex. |
申请公布号 |
WO2012149481(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
WO2012US35672 |
申请日期 |
2012.04.27 |
申请人 |
THE BOARD OF REGENTS ON THE UNIVERSITY OF TEXAS SYSTEM;CUNNINGHAM, KATHRYN;GILBERTSON, SCOTT, R. |
发明人 |
CUNNINGHAM, KATHRYN;GILBERTSON, SCOTT, R. |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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