PREPARATION METHOD FOR MITOSENE SKELETON

摘要

PURPOSE: A manufacturing method of mitomycin framework is provided to be useful for mass production and synthesis of various mytocin derivatives. CONSTITUTION: A manufacturing method of mitomycin framework(7) is processed by cycliaing 6 - (2- bromophenyl amino) -2- hexyne derivative(6) within molecules by palladium(Pd) catalyst represented by reaction equation 1. In the equation 1, R indicates H, phenyl, alkoxyphenyl, dialkoxyphenyl, acetaminophenyl, and alkylcarboxylate. The manufacturing method uses K2CO3 or Cs2CO3 as a base. The solvent of the reaction is N,N- dimethyl formaldehyde(DMF). The palladium catalyst is Pd (OAc) 2, Pd (dba) 2 or Pd (PPh3) 4. [Reference numerals] (AA) LiCi, base