Anti-IL-17 antibodies are identified that are characterized as having a high affinity and slow off rate for human IL-17. The antibodies of the invention may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful in particular for treating autoimmune, inflammatory, cell proliferative and developmental disorders.
申请公布号
HRP20120606(T1)
申请公布日期
2012.10.31
申请号
HR2012P000606T
申请日期
2012.07.23
申请人
ELI LILLY AND COMPANY
发明人
ALLAN, BARRETT;CHOW, CHI-KIN;HUANG, LIHUA;LIU, LING;LU, JIRONG;NG, KINGMAN;TETREAULT, JONATHAN WENDELL;WERNER, ANDREW GORDON