发明名称 |
METHOD FOR MONITORING PRIMARY DRYING OF A FREEZE-DRYING PROCESS |
摘要 |
<p>A freeze-drying process includes a primary drying phase. Within this phase, a test is performed for causing a variation of partial pressure of solvent inside a drying chamber. At the beginning of the test, a product sublimation flux, a total pressure and a partial pressure of the solvent in the drying chamber are measured. A product temperature is estimated at the interface of sublimation at the beginning of the test. The solvent vapor pressure at the interface of sublimation is calculated as is a resistance of a dried layer of the product to the vapor flow of the solvent. Next, a thickness of a frozen layer of the product is calculated and a coefficient of heat transfer between heating surface and product is also calculated. An initial temperature profile of the frozen product is then calculated as is a total pressure in the drying chamber. A value of the product temperature at the interface of sublimation at the beginning of test is determined and a time constant of the freeze-drying process is calculated.</p> |
申请公布号 |
EP2516948(A2) |
申请公布日期 |
2012.10.31 |
申请号 |
EP20100814744 |
申请日期 |
2010.12.22 |
申请人 |
TELSTAR TECHNOLOGIES, S.L. |
发明人 |
FISSORE, DAVIDE;PISANO, ROBERTO;BARRESI, ANTONELLO A. |
分类号 |
F26B5/06 |
主分类号 |
F26B5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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