发明名称 |
Method of producing 4-demethoxydaunorubicin |
摘要 |
<p>The present invention relates to a method for the synthesis of 4-demethoxydaunorubicin (idarubicin) having the chemical structure of formula (I), which involves the demethylation of 3'-Prot-daunorubicin in the presence of a soft Lewis acid. The method of the present invention does not comprise cleavage of the glycosidic linkage at carbon C7, thus resulting in a faster synthesis cycle and an improved yield of the final product.</p> |
申请公布号 |
EP2518077(A1) |
申请公布日期 |
2012.10.31 |
申请号 |
EP20120160375 |
申请日期 |
2012.03.20 |
申请人 |
SYNBIAS PHARMA LTD. |
发明人 |
ZABUDKIN, ALEXANDER;MATVIENKO, VICTOR;MATVYEYEV, ALEXEY |
分类号 |
C07H15/252 |
主分类号 |
C07H15/252 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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