发明名称 |
Phosphoinositide 3-kinase inhibitor compounds and methods of use |
摘要 |
<p>Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R 3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.</p> |
申请公布号 |
EP2518074(A1) |
申请公布日期 |
2012.10.31 |
申请号 |
EP20120177885 |
申请日期 |
2007.12.05 |
申请人 |
F.HOFFMANN-LA ROCHE AG;GENENTECH, INC. |
发明人 |
BAYLISS, TRACY;CCHUCKOWREE, IRINA;FOLKES, ADRIAN;OXENFORD, SALLY;WAN, NAN CHI;CASTANEDO, GEORGETTE;GOLDSMITH, RICHARD;GUNZER, JANET;HEFFRON, TIM;MATHIEU, SIMON;OLIVERO, ALAN;STABEN, STEVEN;SUTHERLIN, DANIEL P;ZHU, BING-YANG |
分类号 |
C07D491/04;A61K31/519;A61K31/5377;A61P35/00;C07D495/04 |
主分类号 |
C07D491/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|