| 摘要 |
<p>Substituted 7-Aza-benzothiophene Compounds as Lipid Kinase InhibitorsAbstractThe present invention relates to substituted 7-aza-benzothiophene compounds and the pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and X are as defined herein. Such compounds are lipid kinase inhibitors especially PI3K and/or mTOR inhibitors. The invention also relates to methods and processes for preparation of compounds of formula (I), to pharmaceutical compositions containing the compounds, and to the method of using the above compounds to treat and/or to prevent lipid kinase and/or PI3 Kinase related lipid kinase (especially PI3 kinase and/or mTOR) activity mediated proliferative diseases such as cancer, inflammatory diseases such as asthma, and disorders commonly occurring in connection with transplantation. *G0000 *</p> |
