发明名称 |
Differentially encoded biological analyzer planar array apparatus and methods |
摘要 |
A method of probing a plurality of analyzer molecules distributed about a detection platform is disclosed. The method includes contacting a test sample to the plurality of analyzer molecules, scanning the plurality of analyzer molecules at a rate relating to a carrier frequency signal, and detecting the presence or absence of a biological molecule based at least in part upon the presence or absence of a signal substantially at a sideband of the carrier frequency signal. A molecule detection platform including a substrate and a plurality of targets positioned about the substrate is also disclosed. Specific analyzer molecules adapted to bind a specific analyte are immobilized about a first set of the targets. Nonspecific analyzer molecules are immobilized about a second set of the targets. The targets positioned about the substrate along at least a segment of a scanning pathway alternate between at least one of the first set and at least one of the second set. A method including providing a substrate for supporting biological analyzer molecules the substrate including at least one scanning pathway is also disclosed. The scanning pathway includes a plurality of scanning targets. Specific biological analyzer molecules adapted to detect a specific target analyte are distributed about a first set of the targets which alternate in groups of at least one with a second set of the targets the second set of the targets not including the specific biological analyzer molecules. |
申请公布号 |
US8298831(B2) |
申请公布日期 |
2012.10.30 |
申请号 |
US20090466943 |
申请日期 |
2009.05.15 |
申请人 |
NOLTE DAVID D.;VARMA MANOJ;REGNIER FRED E.;PENG LEILEI;ZHAO MING;PURDUE RESEARCH FOUNDATION |
发明人 |
NOLTE DAVID D.;VARMA MANOJ;REGNIER FRED E.;PENG LEILEI;ZHAO MING |
分类号 |
G01N21/76 |
主分类号 |
G01N21/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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