发明名称 |
Isolated Polynucleotide encoding modified fab' antibody, expression vector, and transformed host cell |
摘要 |
Disclosed is an isolated polynucleotide encoding a modified Fab' antibody, which includes an Fd chain and an L chain with the Fd chain including a CH1 region and the L chain including a CL region, wherein the modified Fab' antibody further includes a cysteine for binding to a fluorescent dye, and the polynucleotide includes an Fd chain coding region and an L chain coding region linked therebetween in a manner that will allow expression of the modified Fab' antibody. Also disclosed are an expression vector containin the isolated polynucleotide, an isolated transformed host cell containing the expression vector, and a cell culture including the transformed host cell. |
申请公布号 |
US8298836(B2) |
申请公布日期 |
2012.10.30 |
申请号 |
US20040979640 |
申请日期 |
2004.11.02 |
申请人 |
HISADA SUNAO;ITO YUKIKO;MATSUMOTO HIROYUKI;SHIMURA KIYOHITO;KASAI KENICHI;HAMAMATSU PHOTONICS K.K. |
发明人 |
HISADA SUNAO;ITO YUKIKO;MATSUMOTO HIROYUKI;SHIMURA KIYOHITO;KASAI KENICHI |
分类号 |
C07H21/04;C07K16/38;C12N1/20;C12N15/13;C12N15/63;C12N15/70;C12N15/74;C12P21/08;G01N33/531;G01N33/557;G01N33/561;G01N33/563;G01N33/577;G01N33/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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