| 摘要 |
One aspect relates to an automatic injection device containing a pre-loaded charge of medicament for automatically administering the medicament upon actuation thereof. A further aspect relates to a method of providing a medicament containing chamber (350) of an automatic injection device. The automatic injection device comprises a housing (110); a medicament chamber (350) having a first compartment and a second compartment, the first compartment containing a first medicament portion (151) and the second compartment containing a second medicament portion (152) to be mixed with the first medicament portion (151); a seal structure (380) between the first compartment and the second compartment, the seal structure (380) initially in a sealing condition that maintains the first compartment separate from the second compartment; a needle assembly (340) that dispenses the medicament charge from the medicament chamber, the needle assembly (340) comprising a needle (141) and a needle support (343), the needle support (343) for mounting the needle (141) to the medicament chamber (350), the needle support (343) defining a needle assembly chamber (394) having an inner surface that tapers radially inward as it extends axially forward toward a rearward end of the needle, the needle support (343) forming a channel from the medicament chamber (350) to the needle; and an activation assembly (120). Activation of the activation assembly causes (a) the seal structure to be converted from the sealing condition to a mixing condition, (b) the first and second medicament portions (151,152) to be mixed, and (c) the mixed first and second medicament portions to be forced through the needle assembly (340). |
