发明名称 |
BACTERIAL VIRULENCE FACTORS AND VERSIONS FOR APPLYING IT |
摘要 |
FIELD: medicine. ^ SUBSTANCE: there are presented versions of recombinant virulent polypeptides and nucleic molecules coding them with the sequences disclosed in the description, used to prepare a vaccine composition for A/E-pathogen. What is described is a vaccine composition for inducing a response on A/E-pathogen in animals containing said nucleic acid molecule; a cell culture supernatant containing said polypeptide; and/or a bacterium or its preparation having a mutation in its genome in said nucleic acid molecule inducing virulence attenuation, or having nleA gene deletion in a combination with a physiologically acceptable carrier. What is presented is a method for virulence attenuation of A/E-pathogen, involving nleA gene deletion in A/E-pathogen or deletion of one or more said nucleic acids in the A/E-pathogen genome. ^ EFFECT: invention provides producing the effective vaccine. ^ 24 cl, 2 tbl, 27 dwg, 9 ex |
申请公布号 |
RU2465331(C2) |
申请公布日期 |
2012.10.27 |
申请号 |
RU20060118803 |
申请日期 |
2004.10.29 |
申请人 |
DZE JUNIVERSITI OF BRITISH KOLAMBIA;UNIVERSIDAD NAS'ONAL' AUTONOMA DE MEKSIKO |
发明人 |
FINLEJ BRETT;GRJUNKHEJD SAMANTA;DEHN VAN'IN';VALLANS BRJUS;PUEHNTE KHOSE L. |
分类号 |
A61K35/00;A61K38/00;A61K39/02;A61P31/04;C07K14/24;C07K14/245;C07K16/12;C12N15/31;C12Q1/68;G01N33/569 |
主分类号 |
A61K35/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|