| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to using a compound of formula wherein R represents hydrogen, lower alkyl or amino; X-R1 represents -CH2- or -CH(lower alkoxy)- and Y-R2 represents -CH2-, -CH(lower alkyl)-, -O-, -S-, -S(O)- or -S(O)2-; Ar represents phenyl, naphthyl or benzofuranyl rings of which are substituted by one or more substitutes specified in a group consisting of lower alkyl, lower alkyl substituted by halogen, halogen, lower alkoxy, lower alkoxy substituted by halogen, hydroxy, dialkylamino, morpholine, benzyl or O-benzyl; or pharmaceutically acceptable acid addition salts for preparing a drug for treating depression, anxiety disorders, bipolar disorder, schizophrenia, Parkinson's disease, epilepsy, migraine, diabetes, diabetic complications or disorders and disturbances of body temperature homeostasis. Also, the invention refers to specific compounds, to the drug on the basis of declared compounds. ^ EFFECT: there are studied known imidazole derivative, and also there are produced new imidazole derivative showing high affinity to trace amine receptors. ^ 6 cl, 48 ex |
