| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention refers to new heterocyclic compounds of formula I wherein: n and m may have values 0, 1, 2 and 3; the sign (#) in what follows means the potential presence of a chiral centre; R represents optionally substituted C5-C10aryl or 5-6-member hetaryl containing 1-2 heteroatoms specified in nitrogen, oxygen and sulphur optionally condensed with a benzene ring with the substitutes specified in C1-C8alkyl, C1-C8alkoxy, halogen, OH, CF3, NO2, CF3O, COOH, an unsubstituted amino group or mono-C1-6alkyl- or di(C1-6alkyl)substituted amino-group, C1-8alkylsulphanyl, C1-8alkoxycarbonyl; A1 and A2 independently represent optionally substituted 5-6 member saturated, or aromatic azaheterocycle containing 1 to 2 nitrogen atoms in the cycle and optionally condensed with the benzene ring; or to their pharmaceutically acceptable salts or alkyl esters in the form of isolated optical isomers, or their mixtures. Also, the invention refers to a pharmaceutical composition on the basis of the compound of formula I, to a drug on the basis of the compound of formula I, as well as to a method for preparing the compound of formula I. ^ EFFECT: there are prepared new non-peptide heterocyclic low-molecular peptidomimetics of a secretory amyloid peptide precursor sAAP showing an ability to have an effective effect on the processes of formation, storage and restoration of the memory lost in health and none. ^ 10 cl, 4 dwg, 22 ex |
