发明名称 |
MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO |
摘要 |
The present invention relates to compounds of Formula I and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as single pharmaceutical agents or in combination with one or more additional pharmaceutical agents, such as, a DPP-IV inhibitor, a biguanide, an alpha-glucosidase inhibitor, an insulin analogue, a sulfonylurea, an SGLT2 inhibitor, a meglitinide, a thiazolidinedione, or an anti-diabetic peptide analogue, in the treatment of, for example, a disorder selected from: a GPR119-receptor-related disorder; a condition ameliorated by increasing a blood incretin level; a condition characterized by low bone mass; a neurological disorder; a metabolic-related disorder; type 2 diabetes; obesity; and complications related thereto. |
申请公布号 |
WO2012145361(A1) |
申请公布日期 |
2012.10.26 |
申请号 |
WO2012US34022 |
申请日期 |
2012.04.18 |
申请人 |
ARENA PHARMACEUTICALS, INC.;JONES, ROBERT M.;BUZARD, DANIEL J.;HAN, SANGDON;KIM, SUN HEE;LEHMANN, JUERG;YUE, DAWEI;ZHU, XIUWEN |
发明人 |
JONES, ROBERT M.;BUZARD, DANIEL J.;HAN, SANGDON;KIM, SUN HEE;LEHMANN, JUERG;YUE, DAWEI;ZHU, XIUWEN |
分类号 |
C07D213/68;C07D213/71;C07D213/85;C07D231/12;C07D233/60;C07D239/34;C07D239/42;C07D241/04;C07D241/08;C07D241/38;C07D249/06;C07D249/10;C07D257/04;C07D271/06;C07D305/08 |
主分类号 |
C07D213/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|