发明名称 |
METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES |
摘要 |
<p>The present disclosure provides methods of treating a disease in a non-rodent mammal comprising administering to the cerebrospinal fluid (CSF) of the non-rodent mammal an rAAV2 particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner effective to infect an ependymal cell in the non-rodent mammal, wherein the ependymal cell secretes the therapeutic protein so as to treat the disease.</p> |
申请公布号 |
WO2012135857(A9) |
申请公布日期 |
2012.10.26 |
申请号 |
WO2012US31896 |
申请日期 |
2012.04.02 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION;DAVIDSON, BEVERLY, L. |
发明人 |
DAVIDSON, BEVERLY, L. |
分类号 |
C12N15/86 |
主分类号 |
C12N15/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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