| 摘要 |
<p>Method of characterization of skin pigment spot apparent or suspected in a human, comprises comparing expression levels, in skin samples form the spot and unwounded adjacent skin, of at least a dermal gene of a family of extracellular glycoproteins and proteoglycans, where the gene is EFEMP1, ECM1, ASPN, HS3ST6, PAPLN, CHSY1 or FLRT2. Independent claims are included for: (1) a method of evaluating the efficacy of a treatment of skin pigment spots comprising comparing expression levels, in skin samples form the spot after such a spot, before and after treatment, of the dermal gene of the family of extracellular glycoproteins and proteoglycans; (2) an in vitro method for evaluating the efficacy of a treatment of skin pigment spots, comprising comparing, before and after treatment, the level of expression in a representative cellular model of the skin, of the dermal gene of the family of extracellular glycoproteins and proteoglycans or the level of expression or activity of the expression product of the selected gene; (3) cosmetic method of treatment or prevention of skin pigment spot of non-pathological human skin comprising modulating the level of expression or activity of the gene of a family of extracellular glycoproteins and proteoglycans, where the modulation is effected through the use of an antisense molecule, an small interfering (si)RNA or a microRNA; (4) use of a modulator of the expression level or activity of the expression product of the gene, for cosmetic applications in the treatment of non-pathological skin pigment spots, where the modulator is an antisense molecule, siRNA, a microRNA, letrozole or anastrozole; and (5) a modulator of the expression level or activity of the expression product of the dermal gene. ACTIVITY : Dermatological. MECHANISM OF ACTION : Gene expression modulator.</p> |
