发明名称 |
REGIMENS AND COMPOSITIONS FOR AAV-MEDIATED PASSIVE IMMUNIZATION OF AIRBORNE PATHOGENS |
摘要 |
A prophylactic regimen for passively preventing infection with a pathogen which has a typical route of infection through the nasopharynx region of a subject, e.g., an airborne virus typically transmitted through coughing or sneezing. The method involves specifically targeting a subject's nasopharynx with a viral vector comprising an AAV capsid and carrying a nucleic acid sequence encoding an anti-viral neutralizing antibody construct operably linked to expression control sequences, in order to provide for high levels of expression of the anti-viral neutralizing antibody construct in the nasal airway cells. Optionally, the neutralizing antibody construct is expressed under a promoter which is regulated or induced by a small molecule which is delivered separately from the viral vector. In one embodiment, the method permits transfection of a subject's nasopharynx even where the subject has circulating neutralizing antibodies against the AAV capsid. |
申请公布号 |
WO2012145572(A1) |
申请公布日期 |
2012.10.26 |
申请号 |
WO2012US34355 |
申请日期 |
2012.04.20 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;WILSON, JAMES, M.;LIMBERIS, MARIA, P. |
发明人 |
WILSON, JAMES, M.;LIMBERIS, MARIA, P. |
分类号 |
C12N15/861;A61K39/40;A61K39/42 |
主分类号 |
C12N15/861 |
代理机构 |
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主权项 |
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地址 |
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