The present invention provides mutant polypeptides useful as hypoallergens. More specifically the present invention provides mutant Bet v 1 proteins and the use of such polypeptides as hypoallergens for desensitizing against birch pollen allergies. Furthermore, the invention provides vaccine formulations comprising such polypeptides; the use of such formulations; and to methods of vaccination against birch pollen allergy.
申请公布号
CA2833668(A1)
申请公布日期
2012.10.26
申请号
CA20122833668
申请日期
2012.04.18
申请人
TEKNOLOGIAN TUTKIMUSKESKUS VTT
发明人
TAKKINEN, KRISTIINA;LAUKKANEN, MARJA-LEENA;SODERLUND, HANS;JYLHA, SIRPA;HOLKERI, HEIDI;NIEMI, MERJA;ROUVINEN, JUHA