发明名称 |
ANTICANCER FUSION PROTEIN |
摘要 |
A fusion protein comprising domain (a) which is the functional fragment of a hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity; and at least one domain (b) which is the sequence of an effector peptide having anti-proliferative activity against tumour cells, wherein the sequence of domain (b) is attached at the C-terminus or at the N-terminus of domain (a).The fusion protein can be used for the treatment of cancer diseases.
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申请公布号 |
CA2832152(A1) |
申请公布日期 |
2012.10.26 |
申请号 |
CA20122832152 |
申请日期 |
2012.04.19 |
申请人 |
ADAMED SP. Z O.O. |
发明人 |
PIECZYKOLAN, JERZY SZCZEPAN;PAWLAK, SEBASTIAN DOMINIK;ZEREK, BARTLOMIEJ MACIEJ;ROZGA, PIOTR KAMIL;SZAWLOWSKA, URSZULA MARTA |
分类号 |
C07K14/705;A61K38/17;A61P35/00;C12N15/12;C12N15/62 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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