发明名称 |
ACADESINE DERIVATIVES, PRODUCTS AND COMPOSITIONS INCLUDING SAME, THERAPEUTIC USES THEREOF, AND METHODS FOR SYNTHESIZING SAME |
摘要 |
The invention relates to acadesine derivatives as a drug, as well as to said derivatives for the treatment of cancer and particularly for the treatment of chronic myeloid leukemia (CML). The invention further relates to a product containing said derivatives and at least one second active ingredient as a combination product to be simultaneously or separately administered, or administered over time, in the treatment of cancer, as well as to a pharmaceutical composition including said derivatives and a pharmaceutically acceptable carrier. Finally, the invention relates to a method for the in vitro inhibition of the proliferation of cells, including contacting a cell with said derivatives in vitro, and to methods for synthesizing said derivatives. |
申请公布号 |
WO2012143624(A2) |
申请公布日期 |
2012.10.26 |
申请号 |
WO2012FR00147 |
申请日期 |
2012.04.17 |
申请人 |
UNIVERSITE NICE SOPHIA ANTIPOLIS;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE;BENHIDA, RACHID;AUBERGER, PATRICK;MALNUIT, VINCENT;DRIOWYA, MOHSINE;PUISSANT, ALEXANDRE;ROBERT, GUILLAUME |
发明人 |
BENHIDA, RACHID;AUBERGER, PATRICK;MALNUIT, VINCENT;DRIOWYA, MOHSINE;PUISSANT, ALEXANDRE;ROBERT, GUILLAUME |
分类号 |
A61K31/4192;A61K31/7056;A61P35/02;C07D249/06;C07H19/056 |
主分类号 |
A61K31/4192 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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