2',3'-EPOXYPROPYL-3.4-DIHYDROXY BENZENE AND A PROCESS FOR THE PREPARATION THEREOF

摘要

The present invention relates to a 2',3'-epoxypropyl-3,4-dihydroxy benzene as an anticancer agent and a process for the preparation thereof. Chemically, the epoxy compound is more stable because the labile allylic double bond was converted to epoxide. The ally lie double bond of 3,4- dihydroxyallylbenzene of the structure 1 has tendency to conjugate with the double bonds of the benzene ring. The 2',3'-epoxypropyl-3,4-Dihydroxy Benzene showed activity for the first time when tongue cancer cells (HSC-3) are being shown to be affected by epoxy hydroxychavicol. There was growth arrest as well as mortality of tongue cancer cells. Epoxy hydroxychavicol is consistent, stable and effective compound modified form of hydroxychavicol from betel leaf is the first time shown to be killing significantly the tongue cancer cells. Tongue cancer is one of the prevalent oral cancers in India and abroad where no remedy has yet been proposed.