PREPARATION METHOD OF TRIFLUOROSTYRENE COMPOUND

摘要

The present invention provides a method for synthesizing a trifluorostyrene compound, wherein the trifluorostyrene compound shown in formula II is formed from the compound shown in formula I in an inert solvent under basic conditions in the presence of a catalyst. In the formulae, X is selected from Cl, Br or I, and Ar is selected from substituted or unsubstituted C6-20 aromatic rings or substituted or unsubstituted C4-20 heterocyclic groups. The method of the present invention can use tetra(triphenyl)phosphine palladium, Pd(dba)2, or a combination thereof as the catalyst. When Pd(dba)2 is used as the catalyst, it should be used in conjunction with a ligand. In the method of the present invention, the trifluorostyrene compound is synthesized from a widely available fluorine-containing material and various substituted arylboronic acid compounds, which greatly increases the fluorine spectrum yield and significantly lowers the amount of catalyst used, and is thus more suitable for industrial production.