| 发明名称 |
Solution Assay and High Through-Put Screen to Probe Interaction Between Human Cullin-Ring Ligase Complex and HIV-VIF Protein |
| 摘要 |
The present invention relates to large-scale production of ElonginB, ElonginC, Vif, and Cullin5. The present invention provides an assay for screening any agent that inhibits the ability of Vif to bind with Cul5. The invention provides an agent identified by the screening methods and methods of treatment using the identified agent. |
| 申请公布号 |
US2012271036(A1) |
申请公布日期 |
2012.10.25 |
| 申请号 |
US201013504690 |
申请日期 |
2010.10.29 |
| 申请人 |
SMITH HAROLD C.;SALTER JASON D.;WEDEKIND JOSEPH E.;UNIVERSITY OF ROCHESTER |
发明人 |
SMITH HAROLD C.;SALTER JASON D.;WEDEKIND JOSEPH E. |
| 分类号 |
C07K14/00;C07K19/00;C12N5/071;C12N15/62;C12N15/63;C12P21/00;G01N33/566 |
主分类号 |
C07K14/00 |
| 代理机构 |
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