发明名称 |
MONOSPECIFIC AND BISPECIFIC ANTI-IGF-1R AND ANTI-ERBB3 ANTIBODIES |
摘要 |
Provided herein are novel monospecific and bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3. Exemplary antibodies inhibit signal transduction through either or both of IGF-1R and ErbB3. Exemplary polyvalent proteins comprise at least one anti-IGF-1R binding site and at least one anti-ErbB3 binding site. In certain embodiments the binding sites may be linked through an immunoglobulin constant region. Novel antiErbB3 and anti-IGF-1R antibodies (e.g., monoclonal antibodies) are also provided.
|
申请公布号 |
US2012269812(A1) |
申请公布日期 |
2012.10.25 |
申请号 |
US201213451135 |
申请日期 |
2012.04.19 |
申请人 |
BAUM JASON;JOHNSON BRYAN;LUGOVSKOY ALEXEY ALEXANDROVICH;XU LIHUI;KOHLI NEERAJ;FITZGERALD JONATHAN BASIL;ADAMS SHARLENE;MERRIMACK PHARMACEUTICALS, INC. |
发明人 |
BAUM JASON;JOHNSON BRYAN;LUGOVSKOY ALEXEY ALEXANDROVICH;XU LIHUI;KOHLI NEERAJ;FITZGERALD JONATHAN BASIL;ADAMS SHARLENE |
分类号 |
C07K16/46;A61K39/395;A61P35/00;C07H21/04 |
主分类号 |
C07K16/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|