NOVEL RNA APTAMERS AND THE USES THEREOF

摘要

PURPOSE: A novel RNA aptamer having anti-cancer effects and a pharmaceutical composition for treating cancers are provided to be used for diagnosing or treating cancers in which proteins are expressed. CONSTITUTION: A novel RNA aptamer combines with Lin28 or Lin28B protein. The RNA aptamer is selected from a group consisting of nucleotide sequence described in the sequence number 1(SEQ ID NO:1)-29. The cancer diagnostic kit includes the RNA aptamer. The cancer diagnostic kit additionally includes a container for performing and analyzing buffer solutions and detection. A pharmaceutical composition for treating cancers includes RNA aptamer as an active ingredient. The pharmaceutical composition for treating cancers additionally includes a pharmaceutically allowed carrier. A screening method of gene fragment which interacts with Lin28 or Lin28B comprises the following steps: withdrawing common base sequence which is included in the RNA aptamer; searching new gene fragment which includes the common sequence; and selecting the gene fragment which interacts with the Lin28 or Lin28B.