A METHOD FOR RAPIDLY EVALUATING PERFORMANCE OF SHORT INTERFERING RNA WITH NOVEL CHEMICAL MODIFICATIONS
摘要
It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.
申请公布号
EP2513337(A1)
申请公布日期
2012.10.24
申请号
EP20100842465
申请日期
2010.12.09
申请人
MERCK SHARP & DOHME CORP.
发明人
BUTORA, GABOR;DAVIES, IAN, W.;FLANAGAN, WILLIAM MICHAEL;FU, WENLANG;KENSKI, DENISE, M.;QI, NING