发明名称 |
Method for producing 3,7-diaza-bicyclo[3.3.1]nonane compounds |
摘要 |
The invention relates to a one-pot reaction for the production of 3,7-diaza-bicyclo[3.3.1]nonane compounds, wherein in a first step a dicarboxylic acid ester is reacted with a pyridine aldehyde and a primary amine. The piperidone created in this manner is reacted with formaldehyde and a further primary amine in a second step. It is essential to the invention that both reaction steps are carried out in a one-pot variation in a C1-C4 alcohol as the solvent, and that the reaction water created is removed by means of distillation. |
申请公布号 |
US8293910(B2) |
申请公布日期 |
2012.10.23 |
申请号 |
US200913059470 |
申请日期 |
2009.08.17 |
申请人 |
SAJITZ MELANIE;LABORDA STEVE;NAUMANN PETER;WESSLING MICHAEL;CLARIANT FINANCE (BVI) LIMITED |
发明人 |
SAJITZ MELANIE;LABORDA STEVE;NAUMANN PETER;WESSLING MICHAEL |
分类号 |
C07D471/08 |
主分类号 |
C07D471/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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