发明名称 |
Stable and sterile tissue adhesive composition with a controlled high viscosity |
摘要 |
A stable and sterile adhesive composition with a controlled level of high viscosity is disclosed in the present invention. Adhesive compositions with different ranges of viscosity could be prepared by heating the adhesive monomer composition at mild temperature in the presence of pluronic polymer. The viscosity of the adhesive composition is able to be controlled to any desired level. A method of stabilizing the adhesive composition with a desired level of high viscosity is provided by using the combination of free radical and acid stabilizers. Methods for packaging, sterilizing and applying the adhesive in the medical field are also provided. |
申请公布号 |
US8293838(B2) |
申请公布日期 |
2012.10.23 |
申请号 |
US20080214791 |
申请日期 |
2008.06.20 |
申请人 |
ZHANG SHENG;RUIZ RAFAEL;ADHEZION BIOMEDICAL, LLC |
发明人 |
ZHANG SHENG;RUIZ RAFAEL |
分类号 |
A61K31/231;A61K31/215;A61K31/22;A61K31/765;C08J3/215;C08K5/315 |
主分类号 |
A61K31/231 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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