摘要 |
This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula (I): where m is zero or one, n is zero to two, Y is oxygen or -N (R9)-, R1, R2, R3, R4, R5, R9, and Ring A are defined in the specification. Coumarin and quinolone compounds where R1 and R2 together form a fused benzo ring are preferred. The invention also provides compounds of formula (VI) where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity.
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申请人 |
ABBOTT LABORATORIES |
发明人 |
BLACKBURN, CHRISTOPHER;LAI, SU-JEN;CHE, JENNIFER L.;MAGUIRE, MARTIN;PATANE, MICHAEL A.;LAMARCHE, MATTHEW J.;CULLIS, COURTNEY A.;BROWN, JAMES;VASUDEVAN, ANIL;FREEMAN, JENNIFER C.;MULHERN, MATHEW M.;LYNCH, JOHN K.;GAO, JU;WODKA, DARIUSZ;SOUERS, ANDREW J.;IYENGAR, RAJESH;VERZAL, MARY KATHERINE;KYM, PHILIP R. |