| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a novel method of producing 1-acetamido-3,5-dimethyladamantane (1) which can be used in synthesis of the medication memantine. The disclosed method involves reaction of 1,3-dimethyladamantane with acetonitrile in bromotrichloromethane in the presence of water under the action of a Mo(CO)6 catalyst with molar ratio [1,3-dimethyladamantane]:[CH3CN]:[CBrCl3]:[Mo(CO)6]:[H2O]=100:100-150:100-150:1-3:1000-2000, at temperature 140-150C for 5-6 hours. . ^ EFFECT: easy implementation of the method and absence of by-products. ^ 1 cl, 8 ex, 1 tbl |
