| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to medicine and pharmaceutical industry, and concerns a method for preparing a dosage form of alkali or alkali-earth perindopril salts in the amorphous form wherein perindopril in the form of a free acid is dissolved in alcohol, neutralised by an aqueous solution of an alkali or alkali-earth base; thereafter this solution is sprayed over inert substances for preparing a granulate and dried in a warm air flow at 30-50C or in vacuum. Before tableting, the granulate is added with substances for improving tableting or additive active substances, such as diurectics, preferentially indapamide. ^ EFFECT: developing the method for preparing the dosage form of the alkali or alkali-earth perindopril salts in the amorphous form. ^ 7 cl, 5 ex |
