发明名称 |
NOVEL SYNTHETIC PEPTIDES IMPROVING EFFICIENCY OF GENE DELIVERY AND METHOD FOR DELIVERING GENE USING THEM |
摘要 |
PURPOSE: A novel synthetic peptide in which gene transfer efficiency is improved and a gene transfer method using the same are provided to enhance gene delivery ability to cells or inside the organs, thereby being used for a gene transfer. CONSTITUTION: A novel synthetic peptide in which gene transfer efficiency is improved includes comprises the amino acid sequence of the sequence number 1(SEQ ID NO:1) or 2 originated from Tat or NLS (nuclear localization sequence) of HIV(human immunodeficiency virus). The gene transmission peptide is represented by chemical formula 1 or chemical formula 2 (Ya-Xb-Cys-Cys-Xc-Yd). In the chemical formula 1 and 2, X indicates amino acid sequence of the sequence number 1 and Y indicates the amino acid sequence of the sequence number 2. The gene transfer peptide is expressed as the amino acid sequence selected from the sequence number 3-10. In the gene transfer complex, genes to be transferred to the peptide are combined. The gene is DNA or RNA. The composite additionally includes cation liposome.
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申请公布号 |
KR20120115850(A) |
申请公布日期 |
2012.10.19 |
申请号 |
KR20110033419 |
申请日期 |
2011.04.11 |
申请人 |
APTABIO THERAPEUTICS INC. |
发明人 |
LEE, SOO JIN;KANG, HYUN GU;DOH, KYUNG OH |
分类号 |
C07K14/155;A61K9/127;A61K47/42;A61K48/00 |
主分类号 |
C07K14/155 |
代理机构 |
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