PROCOLLAGEN CARBOXY-TERMINAL PROPEPTIDES AS A TARGET AND TREATMENT FOR ANGIOGENESIS RELATED DISEASES

摘要

The present invention relates to the field of angiogenesis. More specifically, the present invention provides methods and compositions for modulating angiogenesis. In a specific embodiment, a method for modulating a blood vessel in a subject in need thereof comprising contacting a cell of the subject with a procollagen carboxy-terminal propeptide, a biologically active fragment or mimetic thereof, thereby modulating the blood vessel.