SCREENING METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES
摘要
The present invention relates to screening methods and pharmaceutical compositions for the treatment of inflammatory bowel diseases. More particularly, the present invention relates to a method for screening a plurality of test substances useful for the prevention or treatment of an inflammatory bowel disease comprising the steps consisting of (a) testing each of the test substances for its ability to restore the integrated stress response and (b) and positively selecting the test substances capable of restoring said integrated stress response. A further aspect of the invention relates to an agent capable of restoring the integrated stress response (ISR) for use in the treatment of an inflammatory bowel disease.
申请公布号
WO2012140208(A1)
申请公布日期
2012.10.18
申请号
WO2012EP56799
申请日期
2012.04.13
申请人
INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);OGIER-DENIS, ERIC;TRETON, XAVIER;PEDRUZZI, ERIC;DANIEL, FANNY