Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize aryl alcohol derivatives as cross-coupling partners. Embodiments of the invention include methods for the amination of aryl sulfamates and carbamates, which are attractive cross-coupling partners, particularly for use in multistep synthesis. Illustrative embodiments include versatile means to use simple derivatives of phenol as precursors to polysubstituted aryl amines, as exemplified by a concise synthesis of the antibacterial drug linezolid.
申请公布号
WO2012094622(A3)
申请公布日期
2012.10.18
申请号
WO2012US20527
申请日期
2012.01.06
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;GARG, NEIL K.;RAMGREN, STEPHEN D.;SILBERSTEIN, AMANDA L.;QUASDORF, KYLE W.
发明人
GARG, NEIL K.;RAMGREN, STEPHEN D.;SILBERSTEIN, AMANDA L.;QUASDORF, KYLE W.