| 摘要 |
The present invention provides a polypeptide having an amino acid sequence based on the sequence shown as SEQ ID No. 1 but comprising one or more mutations compared that sequence, whose expression in vivo is associated with tylosis and/or predisposition to develop cancer. The invention also provides a nucleic acid sequence capable of encoding such a polypeptide; a screening method for determining whether a compound may be useful in the treatment of cancer or inflammatory conditions; and a method for diagnosing cancer in a subject, based on the expression of such a polypeptide. |
