| 摘要 |
[Problem] To provide a marker which serves as a measure for the treatment of breast cancer. [Solution] A kit for the diagnosis of breast cancer, which comprises an anti-LAT1 monoclonal antibody and/or a method for diagnosing breast cancer using an anti-LAT1 monoclonal antibody. Among mammary gland neoplastic lesions, ductal carcinoma in situ, which is malignant, undergoes the expression of LAT1 at a significantly high level compared with intraductal breast papilloma, which is benign. Therefore, an anti-LAT1 monoclonal antibody is useful for the discrimination between the two lesions. Further, LAT1 is expressed at a high level in most of triple-negative infiltrating carcinomas which are negative for all of ER, PgR and HER2 that are conventional molecular targeting markers for breast cancer and for which there is no proper molecular targeted therapy method. Therefore, LAT1 can be used as a novel molecular targeting marker for breast cancer. The expression of LAT1 can be diagnosed by the present immunohistological method, and the development of a molecular targeted therapy method in which LAT1 is targeted is effective. |
