THERAPEUTIC AND DIAGNOSTIC METHOD AND COMPOSITION TARGETING 4IG-B7-H3 AND ITS COUNTERPART NK CELL RECEPTOR

摘要

PROBLEM TO BE SOLVED: To identify novel surface markers that allow a precise detection of neuroblastoma cells.

SOLUTION: The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor-associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate NK cell cytotoxicity. Also provided are compounds that bind 4Ig-B7-H3-expressing cells so as to inhibit or eliminate them. The compounds are particularly useful in the treatment of tumors, inflammatory conditions, infections and transplantation. Also provided are methods for diagnosing disease by detecting a 4Ig-B7-H3 protein.

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