发明名称 |
Methods for Determining Sequence Variants Using Ultra-Deep Sequencing |
摘要 |
The claimed invention provides for new sample preparation methods enabling direct sequencing of PCR products using pyrophosphate sequencing techniques. The PCR products may be specific regions of a genome. The techniques provided in this disclosure allows for SNP (single nucleotide polymorphism) detection, classification, and assessment of individual allelic polymorphisms in one individual or a population of individuals. The results may be used for diagnostic and treatment of patients as well as assessment of viral and bacterial population identification.
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申请公布号 |
US2012264632(A1) |
申请公布日期 |
2012.10.18 |
申请号 |
US201213443629 |
申请日期 |
2012.04.10 |
申请人 |
LEAMON JOHN HARRIS;LEE WILLIAM LUN;SIMONS JAN FREDRIK;DESANY BRIAN;RONAN MICHAEL TODD;DRAKE JAMES;LOHMAN KENTON;EGHOLM MICHAEL;ROTHBERG JONATHAN |
发明人 |
LEAMON JOHN HARRIS;LEE WILLIAM LUN;SIMONS JAN FREDRIK;DESANY BRIAN;RONAN MICHAEL TODD;DRAKE JAMES;LOHMAN KENTON;EGHOLM MICHAEL;ROTHBERG JONATHAN |
分类号 |
C40B30/04;C12Q1/68 |
主分类号 |
C40B30/04 |
代理机构 |
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地址 |
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