METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A NOVEL MTOR COMPLEX
摘要
Provided herein is a novel mTOR-comprising complex, mTORC3, which comprises mTOR and the Ets transcription factor TEL2. Specific mTORC3 binding agents and modulating agents are provided, along with kits and methods for the detection of mTORC3. Methods of modulating the activity of mTORC3 or modulating cell growth and/or survival are also provided. Further provided are methods for screening for mTORC3 binding agents and for mTORC3 modulating agents. Various methods of diagnosis and treatment are further provided.
申请公布号
WO2012142233(A1)
申请公布日期
2012.10.18
申请号
WO2012US33239
申请日期
2012.04.12
申请人
ST. JUDE CHILDREN'S RESEARCH HOSPITAL;GROSVELD, GERARD, C.;HARWOOD, FRANK, C.;KLEIN-GELTINK, RAMON, I.
发明人
GROSVELD, GERARD, C.;HARWOOD, FRANK, C.;KLEIN-GELTINK, RAMON, I.