| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a composition with a controlled dissolution profile of a calcium receptor-active compound. <P>SOLUTION: The pharmaceutical composition comprising an effective dosage amount of the calcium receptor-active compound, chosen from cinacalcet HCI or cinacalcet methanesulfonate, and at least one pharmaceutically acceptable excipient, wherein at least one dosage unit of the composition has the dissolution profile in 0.05 N HCI, measured according to a dissolution test conducted using a USP 2 apparatus at a temperature of about 37°C, and at a rotation speed of about 75 r.p.m., which comprises from about 50% to about 125% of a target amount of the calcium receptor-active compound being released from the composition no later than about 30 minutes from the start of the test. <P>COPYRIGHT: (C)2013,JPO&INPIT |
