发明名称 |
MULTI-COMPONENT ANTIOXIDANT COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND THEIR USE FOR REDUCING OR PREVENTING OXIDATIVE STRESS |
摘要 |
An antioxidant compound is disclosed, along with pharmaceutical compositions and methods of treatment which utilize said compound. The compound is characterized by a peptide including at least three amino acid residues of which at least two are cysteine residues, and a first hydrophobic or non-charged moiety being attached to an amino terminal of the peptide via a first bond and a second hydrophobic or non-charged moiety being attached to a carboxy terminal of the peptide via a second bond, as described herein. Cleavage of the peptide by an intracellular peptidase results in generation of a plurality of antioxidant species, each including one of the cysteine residues, thereby providing for a plurality of different antioxidant species acting in synergy in exerting antioxidation.
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申请公布号 |
US2012264676(A1) |
申请公布日期 |
2012.10.18 |
申请号 |
US201213455155 |
申请日期 |
2012.04.25 |
申请人 |
ATLAS DAPHNE;YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM |
发明人 |
ATLAS DAPHNE |
分类号 |
A61K38/00;A61K38/07;A61K9/18;A61K9/40;A61P3/10;A61P7/02;A61P9/00;A61P9/10;A61P9/12;A61P11/00;A61P11/06;A61P17/16;A61P19/02;A61P25/00;A61P25/16;A61P25/28;A61P25/30;A61P25/34;A61P25/36;A61P27/12;A61P29/00;A61P31/04;A61P31/12;A61P31/14;A61P31/16;A61P31/18;A61P35/00;A61P39/00;A61P39/06;A61P41/00;A61P43/00;C07K5/06;C07K5/08;C07K5/083;C07K5/10;C07K5/103;C07K7/06;C07K7/08;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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