| 发明名称 |
BIVALENT DIAZO BICYCLIC SMAC |
| 摘要 |
The invention relates to diazo bicyclic Smac mimetics that are tethered through a covalent linker to give a bivalent species. Bivalent diazo bicyclic Smac mimetics function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs). The invention also relates to the use of bivalent diazo bicyclic Smac mimetics for inducing or sensitizing cells to the induction of apoptotic cell death. Thus, compounds of the invention are useful in the treatment, amelioration, or prevention of hyperproliferative diseases such as cancer.
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| 申请公布号 |
US2012263675(A1) |
申请公布日期 |
2012.10.18 |
| 申请号 |
US201013503366 |
申请日期 |
2010.10.20 |
| 申请人 |
WANG SHAOMENG;SUN HAIYING;THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
WANG SHAOMENG;SUN HAIYING |
| 分类号 |
A61K31/4184;A61K31/423;A61K31/427;A61K31/428;A61K31/437;A61K31/52;A61K38/17;A61K38/19;A61K39/395;A61M37/00;A61P1/00;A61P9/00;A61P9/10;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P27/02;A61P27/06;A61P29/00;A61P35/00;C07D487/04;C12N5/071 |
主分类号 |
A61K31/4184 |
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