发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF TISSUE FIBROSIS |
摘要 |
Provided are methods of treating tissue fibrosis comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a hyaluron synthase (HAS) or CD44. Further provided are methods of inhibiting myofibroblast invasion, or of reducing matrix deposition in the lung, the methods comprising administering to a subject in need of treatment an effective amount of an agent that inhibits a HAS or CD44. Further provided are methods of determining the progression of pulmonary fibrosis, the methods comprising determining the level of matrix metalloproteinase expression in a cell, and comparing the level of expression to that of a control cell, wherein an increased level of expression relative to the control cell indicates progression of the disease. |
申请公布号 |
WO2012142238(A2) |
申请公布日期 |
2012.10.18 |
申请号 |
WO2012US33246 |
申请日期 |
2012.04.12 |
申请人 |
DUKE UNIVERSITY;NOBLE, PAUL, W.;JIANG, DIANHUA |
发明人 |
NOBLE, PAUL, W.;JIANG, DIANHUA |
分类号 |
G01N33/53 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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