| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide isolated chaperonin 10 polypeptides possessing immunomodulatory activity but lacking or substantially lacking protein folding activity. <P>SOLUTION: When compared with a corresponding wild-type chaperonin 10 polypeptides, the isolated chaperonin 10 polypeptides possessing immunomodulatory activity include at least one amino acid substitution, deletion and/or addition in the roof β-hairpin region. <P>COPYRIGHT: (C)2013,JPO&INPIT |
